Some studies suggest that grape seed extract might help with symptoms of chronic venous insufficiency.
It also might help to slightly lower blood pressure in healthy people and those with high blood pressure, particularly in people who are obese or have metabolic syndrome. But people with high blood pressure should not take high doses of grape seed extract with vitamin C because the combination might worsen blood pressure.
A 2019 review of 15 studies involving 825 participants suggested that grape seed extract might help lower levels of LDL cholesterol, total cholesterol, triglycerides, and the inflammatory marker C-reactive protein. The individual studies, however, were small in size, which could affect the interpretation of the results.
Grape seed extract is rich in polyphenols, which can help to reduce the effects of stress on the body and mind. Polyphenols are substances that are found in many plants and have antioxidant activity.
It can also be helpful with eye stress from glare.
Animal studies have shown that Grape seed extract may suppress bone destruction in inflammatory autoimmune arthritis.
Some studies suggest that grape seed extract can have a protective effect on our liver.